The polyol metabolizing pathway comprising of two enzymes: aldose reductase (AR) and sorbitol dehydrogenase (SDH), converts glucose to fructose. Several biochemical features implicate the polyol pathway as a plausible and important contributor to complications of diabetes. Metabolism through the pathway is accelerated by elevated cytoplasmic glucose concentrations induced by hyperglycemia. The resulting altered concentrations of pathway products and cofactors can cause osmotic stress through multiple mechanisms that include the generation of precursors of advanced glycation end products. Plant extracts have been used to reverse the effects of diabetes complications. The present investigation was to determine the effective dose of methanolic extract of Potentilla fulgens on AR activities in liver, kidney and eye tissues of normal mice using two different routes of administration: intraperitoneal (i.p.) and oral. Administration of extract to the diabetic mice resulted in the inhibition of the AR activity in the liver, kidney and eye tissue as compared to the control group.
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